This standard is formulated for the first time. This standard specifies the test method, test steps and test results of acute oral toxicity test of chemicals by animals. This standard is applicable to the determination of acute oral toxicity of chemicals. This standard is modified to adopt the United Nations Organization for Economic Cooperation and Development (OECD) Chemical Test Method No. 401 "Acute Oral Toxicity Test" (1987). This standard and OECD Chemical Test Method No. 401 have the following differences: --- Editorial modification of OECD Chemical Test Method No. 401; --- Added the preface. GB/T 21603-2008 Chemical Acute Oral Toxicity Test Method GB/T21603-2008 Standard Download Decompression Password: www.bzxz.net
This standard is formulated for the first time. This standard specifies the test method, test steps and test results of acute oral toxicity test of chemicals by animals. This standard is applicable to the determination of acute oral toxicity of chemicals. This standard is modified to adopt the United Nations Organization for Economic Cooperation and Development (OECD) Chemical Test Method No. 401 "Acute Oral Toxicity Test" (1987). This standard and OECD Chemical Test Method No. 401 have the following differences: ———Editorial modification of OECD Chemical Test Method No. 401; ———Added the preface.
class="f14" style="padding-top:10px; padding-left:12px; padding-bottom:10px;"> This standard is modified to adopt the United Nations Organization for Economic Cooperation and Development (OECD) Chemical Test Method No. 401 "Acute Oral Toxicity Test" (1987).
This standard has the following differences from OECD Chemical Test Method No. 401:
---Editorial revisions have been made to OECD Chemical Test Method No. 401;
---The foreword has been added.
This standard is proposed and managed by the National Technical Committee for Standardization of Hazardous Chemicals Management (SAC/TC251). The
responsible drafting unit of this standard: Tianjin Institute of Inspection and Quarantine Science and Technology.
Participating drafting units of this standard: Tianjin Institute of Inspection and Quarantine Science and Technology, Jiangnan University, Sinochem Chemical Standardization Institute, Tianjin Entry-Exit Inspection and Quarantine Bureau, Institute of Occupational Health and Poisoning Control, Chinese Center for Disease Control and Prevention.
Main drafters of this standard: Zhang Yuan, Wang Libing, Zhao Zhuo, Xu Chuanlai, Wang Xiaobing, Yu Zhirui, Li Chaoyang. This standard is formulated
for the first time.
The clauses in the following documents become the clauses of this standard through reference in this standard. For any dated referenced document, all subsequent amendments (excluding errata) or revisions are not applicable to this standard. However, parties to an agreement based on this standard are encouraged to study whether the latest versions of these documents can be used. For any undated referenced document, the latest version applies to this standard.
GB/T21605-2008 Test method for acute inhalation toxicity of chemicals
Technical Specification for Toxicity Identification of Chemicals (2005) of the Ministry of Health

IC$ 13. 300. 11. 100
National Standard of the People's Republic of China
G/21603-2008
Chemicals--Test method of acute oral toxicity
Chemicals--Test method of acute oral toxicity2008-04-01
General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of ChinaStandardization Administration of China
2008-09-01
G/r21603200
This standard adopts the OECD Chemical Test Method N401 of the United Nations Organization for Economic Cooperation and Development (OECD) The standard was issued by the National Hazardous Chemicals Management Committee (SAC/TC1) and the price list of this standard was added. The only affiliated units of this standard are: Tianjian Institute of Science and Technology, Huinan University, China Chemical Standards Institute, Tianjian Environmental Inspection and Quarantine, China Center for Disease Control and Prevention, and China Institute of Safety and Health. The main persons in charge of this standard are: Zhang Xi, Guan Li, Yue Zhuo, Gu Chuanlai, Fei Xiaoying 、下解睿、李期器！ ：This standard is the latest standard for the author
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chemical
acute toxicity test method
GR/*21603--2008
This standard stipulates the test methods for the acute toxicity of chemicals by substances, and the new standard for the test methods for the acute toxicity of chemicals by substances is 2 normative reference documents
the following documents are used for the service The general design of the whole agent can be used as the clauses of this standard. All the terms of this standard are valid! The document is used, and all the revisions are not included (not including the latest revisions of this standard). The latest revisions are not applicable to this standard. The latest revisions are based on the agreement reached by the parties. This document can be used.
G3/T21605-2008
Ministry of Industry and Health Chemical Xin Health Appraisal Technology
3 Soft definition of terms
Download the terminology for this standard
Dragon oral Xin
acute oraf
times put in the mouth
oral half the number of rational dead moments
doubt times or
most: in units of weight house
in multiple songs
scale products
Jing Tong-Friends plate relationship new 0%
installation shows the preparation of chemical things
4 test methods
Egg doctrine
wind period rational twist continues very basic new in this standard elegant. The virtual period of health education version
waldose
tatinashi||tt ||Total number of deaths of drugs
The prime number of the population in the test group is the rate of occurrence of the drug. The drug is dissolved in a suspension. It is recommended to use water-based vegetable oil as the solvent. You can consider using other forms (such as fiber-based cities, glue, and other forms) to prepare mouse-sensitive liquids. It can be prepared into other forms (fine substances) with obvious organic chemical properties. Use a single-gel container to observe the service life. 4.2 Experimental animals
Choose healthy mice (13#-8) (18%20), #optional #other sensitive animals. The sex of the experimental animals shall not change from the average body weight, and the experimental environment of the animals shall be suitable for at least 1-2 weeks. 5.3 Dosage design
The requirements of the method are as follows. The original test should be set up with a small number of animals in each group, generally 1 point, half male and half female, and the interval between each group should be large and the number of animals should be small. If the test product is very low, the maximum method can be adopted, that is, 0 (energy) doses are used to start the animal research company to avoid multiple doses. http
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G8,121603---2008
4.4 Test steps
4.4.1 Test animal feeding-stock 161 in the mouse without limiting the drinking water. We use high-grade experimental animals, the fasting time can be appropriately short.
? During the experiment, the objects were randomly divided into groups and the dosage was changed to the method of changing the dosage before and after the high tide. The volume of the prepared dose should be discussed accordingly. The most commonly used density for mice is 2m1/s. The maximum volume is 10mk. If the dosage is too high, it can be divided into 2~24-hour rooms for drinking and dyeing (1h5 interval per year). As the first step of the experiment, the group was followed by multiple batches of 3h1 dyeing with a density device. The maintenance time is not long. It can be given to infants at any time. 5.1 Observation period and record the life expectancy and death of animals during the observation period. The observation period is generally 14 days. The calculation of observation index 1 is shown in Appendix A of the Ministry of Health and Family Planning, 1-10. The dead animals are checked. After the specified period, the number of survivors is sacrificed and the number of total deaths is roughly controlled if necessary. 5. Calculation of LD by relevant consultants, construction and analysis of sensory products, city skin, general use of the number of hours for analysis, and large-scale test results are shown in Appendix A of the Ministry of Health and Family Planning, 5.3 Interpretation of test results for the test agent LD5. The test can evaluate the acute general adverse reaction of the test product, and the acute adverse reaction of the test product (the classification of chemicals is level 662183 yuan 238) is only reliable. 5.4 Test egg
Test technology manufacturing service concept Na content:
Test sample name interest makeup, preparation method, use feeling: integer explosive system source mixing carving food quality certificate Guangdong Jingan experience! ：……experimental traces of microorganisms, including the source of inquiry, room temperature, standard for the degree of experimental compliance, the combination of agents and the gender of the animals used, the number of clothes you can use, the national health new animal school decline and death situation and the appearance, the general analysis and the observation of the disease and the first and the drug information warm
list my report to do the establishment of the whole equipment of the equipment and the whole equipment of the Ministry of Health of chemical analysis of the complete dragon technical specification
G8/Y 21603-2008
British people's welfare institute
Deputy national standard
Acute oral test method
8t 21333 ---2033
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