This standard is formulated for the first time. This standard specifies the test animals, test procedures, result evaluation and test report for the one-generation reproductive toxicity test of chemicals. This standard is modified to adopt the United Nations Organization for Economic Cooperation and Development (OECD) Chemical Test Method No. 415 "One-generation Reproduction Toxicity Study" (1983). Compared with OECD Chemical Test Method No. 415, this standard has the following differences: - Editorial modifications have been made to OECD Chemical Test Method No. 415; - Added a preface; - Editorial modifications have been made to the standard text format in accordance with GB/T1.1-2000. GB/T 21607-2008 Chemical One-generation Reproduction Toxicity Test Method GB/T21607-2008 Standard Download Decompression Password: www.bzxz.net
This standard is formulated for the first time. This standard specifies the test animals, test procedures, result evaluation and test report for the one-generation reproductive toxicity test of chemicals. This standard is modified to adopt the United Nations Organization for Economic Cooperation and Development (OECD) Chemical Test Method No. 415 "One-Generation Reproduction Toxicity Study" (1983). Compared with OECD Chemical Test Method No. 415, this standard has the following differences: ———Editorial modification of OECD Chemical Test Method No. 415; ———Added the preface; ———Editorial modification of the standard text format according to GB/T 1.1-2000.
class="f14" style="padding-top:10px; padding-left:12px; padding-bottom:10px;"> This standard is modified to adopt the United Nations Organization for Economic Cooperation and Development (OECD) Chemical Test Method No. 415 "One-Generation Reproduction Toxicity Study" (1983).
Compared with OECD Chemical Test Method No. 415, this standard has the following differences:
---Editorial revisions have been made to OECD Chemical Test Method No. 415;
---The preface has been added;
---Editorial revisions have been made to the standard text format in accordance with GB/T1.1-2000.
This standard is proposed and managed by the National Technical Committee for Standardization of Dangerous Chemicals Management (SAC/TC251).
The responsible drafting unit of this standard is Tianjin Institute of Inspection and Quarantine Science and Technology.
Participating drafting units of this standard are Jiangnan University, Sinochem Chemical Standardization Institute, Tianjin Entry-Exit Inspection and Quarantine Bureau, and Institute of Occupational Health and Poisoning Control, Chinese Center for Disease Control and Prevention.
Main drafters of this standard are Zhang Yuan, Wang Libing, Li Xueyang, Zhao Zhuo, Wang Xiaobing, Xu Chuanlai, and Li Chaoyang.
This standard is formulated for the first time.
The clauses in the following documents become the clauses of this standard through reference in this standard. For all dated referenced documents, all subsequent amendments (excluding errata) or revisions are not applicable to this standard. However, parties that reach an agreement based on this standard are encouraged to study whether the latest versions of these documents can be used. For all undated referenced documents, the latest versions are applicable to this standard.
GB14924.1 General quality standard for compound feeds for experimental animals
GB14925 Environment and facilities for experimental animals

513.300:11100
National Standard of the Republic of China
G3/21607--2008
Chemicals
Test method of one-generatin reproduction toxicity
Chemicalsm-Test method of one-generatin reproduction toxicity2008-04-01Published
General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of ChinaStandards Promotion and Administration Commission of China
2008-09-01Implementation
K/1 21607--208
Physical police respect the national economic and comfortable food development organization (learning the law of the case #21983
This standard is still O chemical testing method N3 period than the following difference: E chemical most test method S avoid the end of the combustion repair collection increase the sound part
Standard meaning of this capital Wuhan University according to B200 after the compilation of the solution can be modified this paint filling of the whole difficult dangerous chemical management standard difficult chemical teaching and nutrition association (511) cover out and manage the project The planning unit of the standard is: Tianjin Institute of Inspection and Quarantine Science and Technology. The participating units are: Tianjin University, China Chemical Institute, Tianjin Environmental Protection Bureau, Center for Toxic Science and Technology, Center for Disease Control and Prevention, Institute of Toxic Science and Technology. The main organizers are: Zhang Hui, Wang Chengji, Li Daixiang, Zhao Yuan, Zhu Wanbing, Dai Chao, etc. This standard is formulated for the second time, test method for toxicity of chemicals for reproduction, B/1 21807--2008
This standard specifies the test animals, test results and test reports for the performance test of chemicals. This standard shall be used to test the test animals and test results of chemicals. 2 Normative references
The following documents are cited as the provisions of this standard. All the referenced documents shall not be applicable to this standard unless they have been revised or updated by the research unit. However, the latest revision of the referenced documents shall be applicable to this standard. The latest revision of the referenced documents without date shall be selected as the referenced documents. G3 [8924.7
GB1925
3 Terms and definitions
Third to
's elegance or wine
refers to technical education
non-transmitted non-introduction
4 Experimental animals
long hair has
4.1 Selection of species and quality
Prefer healthy new elephants or small animals
bin test, male monster teaching
4.2 Number of animals
sex and temperament are common! !
Part photo #3 Beiyou has
4. 3. The feeding environment should be low, such as the decline of reproduction rate, or the generation of 8. The research center should ensure that the number of animals in the fog box is normal and the experimental animals can meet the requirements of B14924.1 and G14. When testing new animals, they should be kept separately and the bedding should be changed in the cages when necessary. 5. Test steps 5.1. Before infection, the animals should be randomly divided into control and control groups according to their weight. If the test sample causes a decrease in the food intake and interest rate of the animals, the test group animals should be fed with the same amount of warm water as the test animals. 5.2. The dose should be set up at least three reliable control dimensions in the test. The dose should be as fast as possible to stimulate the existence of the technical results of the cold algebra. The dose can play a light role in the scientific results of the bacteria. The dose should be as low as possible and can not afford the cost of the animals and the contribution of the generation. If the sample is accepted, the dose can be reached! 000#/kg, it still has no effect on the process of complex value, and the maximum test limit can be accumulated, that is, the test number does not need to set up other groups. If the high full dose lock test is observed to have a clear effect on the swimming ability, but has no effect on the life, this is because the purchase of the rat Gao Xin Lu Han
G8/T 21607---2008
5.3 Dyeing
Niu Xin Ai City sample has been sold double-loaded with poison. The amount should be found in the body of the animal to confirm the cage. It is rarely used to adjust you. The opponent is good and reliable. The health of the vegetable bottle is calculated according to the most common days of pregnancy. 5.4 Poisoning time and management seat take rats as an example. Work now thin 1) Xiang 1 poisoning attached time and procedure
said the risk of leaving period
The 18th home
9 reduce ~ wear 1 week tableWww.bzxZ.net
The first [2 Week 3-17th period
5.5 Signing mating procedure
Concluded the more reliable sex prevention animal
Empty, place the animal
sex to continue
Read the correct number of medical teaching standards can be a good substitute for the animal 5.5.1 The waist and female animals according to the ratio of 1:2. Hand F
F1 out of practice
Determine the family fortune
55.2 The female rats should be given the final and the penalty group of male rats to feed the pets directly, the longest time can be 3. The day of the examination of spermatogenesis is counted as the day of pregnancy (the animal is judged to be mating merit) 5.6 The idea of ​​the case
out of the year is 1 day, the number of litters should be random without carbon 4. If the scientists cannot find the answer to the question during the 4 and 1 test, the minimum number of offspring per year shall be 5.7. Observation and inspection
5.7.1 Observe the animals for each group and observe whether there are any behavioral changes, group reproduction and the benefits of the group (including death).
5.7.2 Body weight and food intake
5.72.1 During mating and mating period, the amount of food consumed per day (mating period and night mating period) shall be determined separately Xie Hualiu calculated,
5, for 22 years, fresh food has been used to instantly rectify the tax on the body, and the food intake of people should be recorded in accordance with the state food grace seal. 5.7, 2.3 The sample should be added to the water to avoid giving the sample, that is, the water intake should also be recorded, 5.7.2.4 The parent animals should be added to the group on the first day of the old line, and each subsequent drama is called Dai body benefits -~: 5.7, 2.5 The gestational period should be calculated from the first day of pregnancy, and the existence of mice under strict supervision should be considered early, and the most accurate number of each should be recorded, as well as the number of young people and whether there is any difference in appearance. 5.7.3 Gross examination
Perform a gross examination on all deceased parent animals, observe morphological changes in tissues and organs, identify the deceased, and confirm the existence of the deceased. 5.7.4 Histopathological examination
Perform a gross examination on all deceased parent animals, observe morphological changes in tissues and organs, and ensure the existence of the deceased. The parent animals were dissected, and the uterus, uterus, testicles, sperm, prostate, submental corpus callosum and target organs were examined. The specimens of the animals in the control group and the control group were examined for abnormalities. If significant lesions were found in the experimental group, no further pathological examination was required. If significant lesions were found in the experimental group, the relevant specimens of the other experimental groups were also examined. 6 Conclusion Evaluation
6.1 The number of breeding phosphorus
mating rate (must be two "mating play animal teaching period for the ability of animal stimulation text pregnancy (change grass animal number related to the actual mating of Dai Niu animal number) text 0 full production ((strict life task of the Yao batch number / season number of animals) × I survival (gift young survival number, birth rate of blue time number of articles 100 instant breeding or alive) (! New trend of young survival number / birth period good storage number 6. Data processing
G/121607.--2008
, 2.! Moment flow test number with, the table shows the quality of the animal number of acid, mating The number of sexually active animals, the number of sexually active animals, the percentage of animals that should be subtracted from the total number
6, the logarithmic statistical method should be used to perform statistical analysis: 6.3 The reproductive index of the animals in the sexual group and the control group should be compared to determine whether the test samples have reproductive ability. At the same time, statistical indicators (such as the main points of observation and the characteristics of the tissue culture) can also be used to observe the reproductive characteristics. The test report
The test questions are all included in the following content!
Test sample name, physical and chemical characteristics, formula, strain, sex, period, animal quality, certification number, animal level, experimental animal breeding environment, source of seasoning, temperature, relative explosion limit, pet breeding method, duration, dosage form, etc.The original material of the animal
"... the sex and dosage of the most components of the clothing, the cumulative symptoms of the sexual response, including the growth and development of the animal;... the time of stillbirth in the experimental animals to the end of the experiment, the average life expectancy of the animal, and the amount of acid in the late stage of the experiment... any relevant information, the cumulative effect of the growth and development of the animal, the duration of the various abnormal symptoms observed... a general explanation The results of the test: Detailed explanation of the test results: The test results were given in detail. The test animals were exposed to the test samples for multiple times and the test results were compared with the results of the teratogenic test. The test results were not effective in human consumption and the product was not suitable for human consumption. GB/7 21607-2008
Chinese Tiger Republic
Pictures
Modern Medical Colony Test Methods
8B'T 2180?2008
China Standard Publishing House
North China Standard Publishing House
North China Standard Publishing House
Summary: 10914:
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Tel: 5853394665517549
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2008 June
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