This standard specifies the terms and definitions, evaluation procedures and scope of chemicals for hazard evaluation of chemicals. This standard applies to chemical production units and import units for hazard evaluation of chemicals they produce or import. This standard does not apply to radioactive chemicals, cosmetics, pharmaceuticals, veterinary drugs, military chemicals and polymers, but when the polymer contains the amount of unpolymerized monomers specified in this standard, the monomers need to be evaluated. GB/T 22225-2008 General Rules for Hazard Evaluation of Chemicals GB/T22225-2008 Standard Download Unzip Password: www.bzxz.net
This standard specifies the terms and definitions, evaluation procedures and scope of chemicals for hazard evaluation of chemicals. This standard applies to chemical production units and import units for hazard evaluation of chemicals they produce or import. This standard does not apply to radioactive chemicals, cosmetics, pharmaceuticals, veterinary drugs, military chemicals and polymers, but when the polymer contains the amount of unpolymerized monomers specified in this standard, the monomers need to be evaluated.
The consistency of this standard with the EU Regulation on Registration, Evaluation, Authorization and Restriction of Chemicals [Regulation (EC) No. 1907/2006 of the European Parliament and of the Council] is non-equivalent, and the relevant technical contents are basically the same.
Appendix A of this standard is a normative appendix.
This standard is proposed and managed by the National Technical Committee for Hazardous Chemicals Management Standardization (SAC/TC251). The
responsible drafting unit of this standard: Chemical Registration Center of the State Administration of Work Safety.
Participating drafting unit of this standard: Qingdao Safety Engineering Research Institute of Sinopec.
Main drafters of this standard: Li Yuncai, Guo Xiuyun, Cao Yongyou, Li Yongxing, Li Xuehua, Chen Jun, Ji Guofeng, Mu Jingxia, Guo Zongzhou, Zhang Haifeng.
The clauses in the following documents become the clauses of this standard through reference in this standard. For all referenced documents with dates, all subsequent amendments (excluding errata) or revisions are not applicable to this standard. However, parties that reach an agreement based on this standard are encouraged to study whether the latest versions of these documents can be used. For all referenced documents without dates, the latest versions are applicable to this standard.
GB15258 Provisions for the preparation of chemical safety labels
GB20576 Safety specifications for classification, warning labels and warning statements of
chemicals - Explosives GB20577 Safety specifications for classification, warning labels and warning statements of chemicals - Flammable gases
GB20578 Safety specifications for classification, warning labels and warning statements of chemicals - Flammable aerosols
GB20579 Safety specifications for classification, warning labels and warning statements of chemicals - Oxidizing gases
GB20580 Safety specifications for classification, warning labels and warning statements of chemicals - Gases under pressure
GB20581 Safety specifications for classification, warning labels and warning statements of chemicals - Flammable liquids
GB20582 Safety specifications for classification, warning labels and warning statements of chemicals - Flammable solids
GB20583 Safety specifications for classification, warning labels and warning statements of chemicals - Self-reactive substances
GB20584 Safety specification for classification, warning labels and warning statements of chemicals Self-heating substances
GB20585 Safety specification for classification, warning labels and warning statements of chemicals Spontaneous ignition liquids
GB20586 Safety specification for classification, warning labels and warning statements of chemicals Spontaneous ignition solids
GB20587 Safety specification for classification, warning labels and warning statements of
chemicals Substances that emit flammable gases in contact with water GB20588 Safety specification for classification, warning labels and warning statements of chemicals Corrosive substances to metals
GB20589 Safety specification for classification, warning labels and warning statements of chemicals Oxidizing liquids
GB20590 Safety specification for classification, warning labels and warning statements of chemicals Oxidizing solids
GB20591 Safety specification for classification, warning labels and warning statements of chemicals Organic peroxides
GB20592 Safety specification for classification, warning labels and warning statements of chemicals Acute toxicity
GB20593 Safety specification for classification, warning labels and warning statements of
chemicals Skin corrosion/irritation GB20594 Safety specification for classification, warning labels and warning statements of chemicals Serious eye damage/eye irritation
GB20595 Safety specification for classification, warning labels and warning statements of chemicals Respiratory or skin sensitization
GB20596 Safety specification for classification, warning labels and warning statements of chemicals Germ cell mutagenicity
GB20597 Safety specification for classification, warning labels and warning statements of chemicals Carcinogenicity
GB20598 Safety specification for classification, warning labels and warning statements of chemicals Reproductive toxicity
GB20599 Safety specification for classification, warning labels and warning statements of chemicals Specific target organ toxicity - single exposure
GB20601 Safety specification for classification, warning labels and warning statements of chemicals Specific target organ toxicity - repeated exposure
GB206029 0 TD(_ Chemical classification, warning labels and warning statements Safety regulations Hazards to the aquatic environment

ICS13.300
National Standard of the People's Republic of China
GB/T 22225-—2008
General provisions for hazard evaluation of chemicals
General provisions for hazard evaluation of chemicals2008-06-19Promulgated
General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of ChinaStandardization Administration of the People's Republic of China
2009-02-01Implementation
GB/T22225—2008
This standard is not equivalent to the EU Regulation on Registration, Evaluation, Authorization and Restriction of Chemicals [Regulation (EC) No. 1907/2006 of the European Parliament and of the Council], and its relevant technical contents are basically the same. Appendix A of this standard is a normative appendix.
This standard is proposed and managed by the National Technical Committee for Standardization of Hazardous Chemicals Management (SAC/TC251). The responsible drafting unit of this standard is the Chemical Registration Center of the State Administration of Work Safety. The participating drafting unit of this standard is the Qingdao Safety Engineering Research Institute of Sinopec. The main drafters of this standard are Li Yuncai, Guo Xiuyun, Cao Yongyou, Li Yongxing, Li Xuehua, Chen Jun, Ji Guofeng, Mu Jingxia, Guo Zongzhou and Zhang Haifeng.
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1Scope
General principles for hazard evaluation of chemicals
GB/T 22225—2008
This standard specifies the terms and definitions of hazard evaluation of chemicals, the evaluation procedures and the scope of evaluated chemicals. This standard is applicable to the hazard evaluation of chemicals produced or imported by chemical production units and import units. The chemicals evaluated by this standard are chemicals belonging to substances. This standard does not apply to radioactive chemicals, cosmetics, medicines, veterinary drugs, military chemicals and affinity compounds. However, when the compounds contain the uncombined monomers specified in this standard, the monomers need to be evaluated. 2 Normative references
The clauses in the following documents become the clauses of this standard through reference in this standard. For all dated referenced documents, all subsequent amendments (including errata) or revisions are not applicable to this standard. However, the parties who reach an agreement based on this standard are encouraged to study whether the latest versions of these documents can be used. For all undated referenced documents, the latest versions are applicable to this standard. 3 Provisions for the preparation of chemical safety labels
GB 15258
GB 20576
Safety specifications for classification, warning labels and warning statements of chemicals Explosives
Safety specifications for classification, warning labels and warning statements of chemicals Flammable gases
GB20577
GB20578
GB 20579
Safety specifications for classification, warning labels and warning statements of chemical warfare Flammable aerosols
Safety specifications for classification, warning labels and warning statements of chemicals Safety specifications for classification, warning labels and warning statements of chemicals GB20580
Safety specifications for classification, warning labels and warning statements of chemicals GB 20581
GB20582
Safety specification for classification, warning labels and warning statements of chemicalsSafety specification for classification, warning labels and warning statements of chemicalsGB 20583
Safety specification for classification, warning labels and warning statements of chemicalsGB 20584
GB20585
G20586
GH20587
GB 20588
GB20589
GB20590
GB20591
GB20592
GB20593
GB 20594
GR20595
G20596
GR20597
GB 20598
GB20599
GB20601
GB20602
Safety specifications for chemical classification, warning labels and warning statementsSafety specifications for chemical classification, warning labels and warning statementsSafety specifications for chemical classification, warning labels and warning statementsSafety specifications for chemical classification, warning labels and warning statementsSafety specifications for chemical classification, warning labels and warning statementsSafety specifications for chemical classification, warning labels and warning statementsSafety specifications for chemical classification, warning labels and warning statements Safety regulations for chemical classification, warning labels and warning statements Safety regulations for chemical classification, warning labels and warning statements Safety regulations for chemical classification, warning labels and warning statements Safety regulations for chemical classification, warning labels and warning statements Safety regulations for chemical classification, warning labels and warning statements Safety regulations for chemical classification, warning labels and warning statements Safety regulations for chemical classification, warning labels and warning statements Safety regulations for chemical classification, warning labels and warning statements Safety regulations for chemical classification, warning labels and warning statements Safety regulations for chemical classification, warning labels and warning statements Httn
Oxidizing Gases
Gases under pressure
Flammable liquids
Flammable solids
Self-reactive substances
Self-heating substances
Pyrophoric liquids
Pyrophoric solids
Substances which, in contact with water, emit flammable gases
Corrosive to metals
Oxidizing liquids
Oxidizing solids
Organic peroxides
Acute effects
Skin corrosion/irritation
Serious eye damage/eye irritation
Respiratory or skin sensitization
Germinal sinus Denaturation
Tumorigenicity
Reproductive toxicity
Specific target organ systemic toxicity Single exposure Specific target organ systemic toxicity Repeated exposure Hazards to the aquatic environment
GB/T22225—2008
EU Regulation on Registration, Evaluation, Authorization and Restriction of Chemicals Regulation (EC) No. 1907/2006 of the European Parliament and of the Council of the European Union II
United Nations Globally Harmonized System of Classification and Labelling of Chemicals (GHS) (First Revision) 3 Terms and Definitions
The following terms and definitions apply to this standard. 3.1
Substances
Chemical elements and their compounds in the natural state or obtained by any production process, including any additives necessary to maintain their stability and any impurities produced during the processing, but excluding any separable solvents that will not affect the stability of the substance or change its composition.
Article
Objects with a specific shape, appearance or design, which determine their functions more than their chemical composition. 3.3
Chemicals
Various chemical elements, compounds composed of elements and their mixtures. 3.4
Hazardous chemicals
Dangeroogchemicals
Chemicals with properties such as explosion, combustion, combustion-supporting, poisonous, corrosive, and environmental hazards, which may cause harm or damage to people, facilities, and the environment in contact with them.
Polymer
Long-chain macromolecules with a degree of polymerization greater than or equal to 3 formed by the polymerization of one or more monomers. 3.6
Manufacturer
An entity engaged in the production of chemicals, including a research and development unit that conducts pilot-scale expansion of chemicals. 3.7
Importer
An entity engaged in the import of chemicals.
Has properties.
Bioconcentration factor, BCF is the ratio of the concentration of a chemical in a living organism to its concentration in the environmental medium. 3.9
Persistent chemicals are chemicals that can persist in the environment, accumulate through the biological food chain (web), and cause harmful effects on human health. 3.10
Biologically Accumulative Chemicals
Chemicals that accumulate in the food chain or are easily enriched in the organism through the surrounding media and reach a medium concentration through the biomagnification of the food chain. When the rate of uptake and storage of a substance in an organism is higher than its metabolism (decomposition) or excretion rate, accumulation occurs. 3.11
Downstream user
downstream user
GB/T 22225—2008
Any natural or legal person who uses a substance by itself or in a mixture in his production or professional activities other than a production unit or an importing unit. Distributors or consumers are not downstream users. 3.12
No observable effect concentration NoEC The maximum concentration at which no effect related to the test sample is observed under the specified test conditions using the existing technical means or detection indicators.
4 Evaluation procedure
4.1 Preliminary preparation
Collect and organize various information and data of the evaluated chemicals. When key data is missing, the evaluation unit shall request the production unit to conduct tests and inspections or request relevant data from the importing unit. 4.2 Hazard identification
Identify the hazards of chemicals based on the physical properties, chemical properties and hazards of the chemicals. 4.3 Determine the evaluation objectives and contents
4.3.1 Evaluation objectives
4.3.1.1 Determine the category and symbol of the chemical hazard and whether it is a persistent, bioaccumulative and toxic chemical or a highly persistent and highly bioaccumulative chemical;
4.3.1.2 Evaluate whether the chemical has physical hazards, health hazards and environmental hazards; 4.3.1.3 For hazardous chemicals or persistent, bioaccumulative and toxic chemicals or highly persistent and highly bioaccumulative chemicals, put forward control measures or suggestions for chemical hazards based on the exposure of workers and environmental emissions. 4.3.2 Evaluation contents
4.3.2.1 Physical hazards
Mainly evaluate the following hazards that chemicals may have: a) Explosiveness, b) Combustibility:
) Oxidizing property
d) High-pressure gas hazard;
Metal corrosion.
4. 3. 2. 2 Health Hazards
Mainly evaluate the following hazards that chemicals may have: a) acute toxicity; b) skin corrosion/irritation; c) serious eye damage/eye irritation; respiratory or skin allergy; e) specific target organ systemic toxicity (single exposure and repeated exposure); f) carcinogenicity, mutagenicity and reproductive toxicity.
4.3.2.3 Environmental Hazards
Mainly evaluate the following hazards that chemicals may have: a) Impact on the aquatic environment (including sediments); b) Impact on the terrestrial environment;
c) Impact on the atmosphere;
Potential impact through accumulation in the food chain; d
e) Potential impact on biological activities in sewage treatment systems: 3
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GB/T 22225—2008
f) Persistence, bioaccumulation and toxicity or high persistence and commercial bioaccumulation evaluation. 4.4 Evaluation
4.4.1 Physical Hazard
4. 4. 1. 1 Classification and Labeling
Collect or obtain through testing the data on the explosiveness, flammability, oxidizability, high-pressure gas hazard, metal corrosivity, etc. of the evaluated chemicals. According to GB20576~GB20591, determine whether the evaluated chemicals are physically hazardous chemicals, classify the chemicals with physical hazards and determine their labels.
4.4.1.2 Evaluation
Evaluate the physical hazard of the chemicals based on all the physical, chemical, flammable, explosive and corrosive data of the chemicals. 4.4.2 Health Hazards
4.4.2.1 Classification and Labeling
Collect or obtain data on the acute toxicity, irritation, skin corrosion, sensitization, carcinogenicity, mutagenicity, reproductive toxicity, etc. of chemicals through experiments. According to GB20592~GB20599 and GB20601, determine whether the evaluated chemicals are health hazard chemicals, classify those that are health hazard chemicals and determine their labels. 4.4.2.2 Evaluation
Based on research data from all aspects such as population epidemiological surveys, toxicological tests, and health monitoring, evaluate the harmful effects and intensity of the chemicals to be evaluated after contact with the body. 4.4.3 Environmental Hazards
4.4.3.1 Classification and Labeling
Collect or obtain data on the environmental hazards of chemicals through experiments. According to GB20602, determine whether the evaluated chemicals are environmental hazard chemicals, classify those that are environmental hazard chemicals and determine their labels. 4.4.3.2 Evaluation
Evaluate the environmental hazards of chemicals based on all environmental data of chemicals. 4.4.3.3 Evaluation of persistence, bioaccumulation and toxicity or high persistence and high bioaccumulation According to the judgment method of persistence, bioaccumulation and toxicity and high persistence and high bioaccumulation chemicals (see Appendix A), determine whether the evaluated chemical is persistent, bioaccumulative and toxic or high persistence and high bioaccumulation chemicals. 4.4.4 Comprehensive evaluation
According to the classification and marking of the physical hazards, health hazards and environmental hazards of the evaluated chemicals, the hazard classification and marking of the evaluated chemicals are comprehensively obtained.
According to the physical hazards, health hazards and environmental hazards of the evaluated chemicals, the hazard of the evaluated chemicals is comprehensively obtained. 4. 4.5 Hazard prevention and control recommendations
If the evaluated chemical is a hazardous chemical or a persistent, bioaccumulative and toxic chemical or a highly persistent and highly bioaccumulative chemical, analyze the main use of the production unit or import unit The workplace and environmental emissions are analyzed, and control measures or recommendations for chemical hazards are proposed.
4.5 Preparation of Chemical Hazard Assessment Report
4.5.1 Report Contents
Chemical Hazard Assessment Report shall include the following contents. 4.5.1.1 Evaluation Conclusion and Hazard Prevention and Control Recommendationsa) Evaluation Conclusion
b) Hazard Prevention and Control Recommendations
Describe the hazard prevention and control measures that should be taken and have been taken, and state that the measures have been passed on to downstream users. 4.5.1.2 Overview
a) Evaluation Basis
GB/T 22225-—2008
Related laws, regulations and technical standards for evaluation; chemical hazard test identification and adjustment reports and authoritative data materials; other materials for evaluation reference.
b) Introduction to the chemical evaluation unit
c) Introduction to the production process
4.5.1.3 Description of chemical properties
a) Description of physical and chemical properties
b) Description of use
4.5.1.4 Evaluation
Physical hazard assessment
Health hazard assessment
Environmental hazard assessment
Comprehensive evaluation
Recommendations for hazard prevention and control
4.5.2 Report format and requirements
4.5.2.1 Format
a) Cover
Title (××× Hazard Assessment Report), name of the organization and evaluation unit, report number, report version. b) Foreword
e) Contents
d) Text
e) Appendix
4.5.2.2 Basic requirements
a) Paper: A4, white inner text (paper), 70g or more; b) The text shall be in Songti size 4 font.
5 Scope of chemical evaluation
5.1 Quantity of substances produced or imported
The quantity of substances in chemicals produced or imported by production units and importing units is greater than or equal to 10t/a, and a hazard evaluation is required. For substances in mixtures, the quantity is greater than or equal to 10t/a, and one of the following conditions is met, a hazard evaluation is required: a) The concentration of the substance is greater than or equal to the concentration limit specified in the classification standard for hazardous chemicals; h) The mass fraction of unpolymerized monomers in the mixture is greater than or equal to 2%; c) It is a persistent, bioaccumulative and toxic chemical or a highly persistent and highly bioaccumulative chemical, and the mass fraction is greater than or equal to 0.1%.
5.2 Evaluation of Similar Substances
Substances with similar physical and chemical properties, toxicological properties and ecotoxicological properties, or substances that follow a certain regular property due to similar structure, can be evaluated as a group or "a class of substances". 5
GB/T 22225-2008
Appendix A
(Normative Appendix)
Methods for Identifying Persistent, Bioaccumulative and Toxic Chemicals and Very Persistent and Very Bioaccumulative Chemicals
This appendix specifies the identification methods for persistent, bioaccumulative and toxic chemicals and very persistent and very bioaccumulative chemicals. This appendix does not apply to inorganic substances, but applies to organometallic compounds. A.1 Persistence, bioaccumulative and toxic chemicals A.1.1 Persistence
Chemicals that meet one of the following conditions are persistent chemicals: a) half-life in seawater is greater than 60 days;
b) half-life in marine sediments is greater than 180 days; c) half-life in freshwater or estuarine sediments is greater than 120 days; d) half-life in soil is greater than 120 days. A.1,2 Bioaccumulation
Chemicals that meet the following conditions are bioaccumulative chemicals: bioconcentration factor is greater than 2000.
The evaluation of bioaccumulation will be based on bioconcentration measurement data of aquatic organisms. Data from both aquatic and marine species can be used.
A. 1. 3 Toxicity
Chemicals that meet one of the following conditions are classified as toxic chemicals: a) For marine and freshwater organisms, the no observable effect concentration is less than 0.01 mg/L; b) It is a carcinogenic chemical, a mutagenic chemical or a reproductive toxic chemical; c) It is a chemical with other chronic toxicity. A,2 Highly persistent and highly bioaccumulative chemicals A, 2. 1 Highly persistent
Chemicals that meet one of the following conditions are classified as highly persistent chemicals: a) The half-life in seawater, freshwater or estuarine water is greater than 60 days; b) The half-life in seawater, freshwater or estuarine water sediments is greater than 180 days; c) The half-life in soil is greater than 180 days. A.2. 2 Bioaccumulation
Chemicals that meet the following conditions are classified as highly bioaccumulative chemicals: The bioconcentration factor is greater than 5000
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