This standard specifies the diagnostic criteria and treatment principles for occupational chronic n-hexane poisoning. This standard is applicable to the diagnosis of chronic poisoning caused by long-term exposure to n-hexane in occupational activities. The diagnosis of chronic n-hexane poisoning caused by non-occupational factors can also refer to this standard. GBZ 84-2002 Occupational chronic n-hexane poisoning diagnostic criteria GBZ84-2002 standard download decompression password: www.bzxz.net

ICS 13.100
National Occupational Health Standard of the People's Republic of China GBZ84-2002
Diagnostic Criteria of Occupational Chronic n-Hexane PoisoningPublished on April 8, 2002
Implemented on June 1, 2002
Published by the Ministry of Health of the People's Republic of China
Article 6.1 of this standard is recommended, and the rest are mandatory. This standard is formulated in accordance with the Law of the People's Republic of China on the Prevention and Control of Occupational Diseases. N-hexane is an organic solvent commonly used in industrial production. In occupational activities involving exposure to n-hexane, workers may suffer from chronic poisoning due to poor ventilation or improper protection in the workplace. This standard is formulated to effectively prevent and control chronic n-hexane poisoning and protect the health of workers.
This standard is formulated based on the principle of being consistent with the general standards of occupational acute chemical poisoning, highlighting the characteristics of chronic n-hexane poisoning, and striving to be suitable for practical application. It is based on summarizing and analyzing the clinical research progress of chronic n-hexane poisoning in the past 30 years at home and abroad. Appendix A of this standard is an informative appendix.
This standard is proposed and managed by the Ministry of Health of the People's Republic of China. This standard is drafted by the Guangdong Provincial Institute of Occupational Disease Prevention and Treatment and the Health and Epidemic Prevention Station of Shenzhen City, Guangdong Province. The Bao'an District Health and Epidemic Prevention Station of Shenzhen City, Guangdong Province and the Longgang District Health and Epidemic Prevention Station of Shenzhen City, Guangdong Province participated in the drafting. This standard is interpreted by the Ministry of Health of the People's Republic of China. Occupational chronic n-hexane poisoning diagnostic standard GBZ84-2002
Occupational chronic n-hexane poisoning refers to a disease with peripheral nerve damage caused by long-term exposure to n-hexane in workers' occupational activities.
1 Scope
This standard specifies the diagnostic criteria and treatment principles for occupational chronic n-hexane poisoning. This standard applies to the diagnosis of chronic poisoning caused by long-term exposure to n-hexane in occupational activities. The diagnosis of chronic n-hexane poisoning caused by non-occupational factors can also refer to this standard. 2 Normative references
The clauses in the following documents become the clauses of this standard through reference in this standard. For all dated references, all subsequent amendments (excluding errata) or revisions are not applicable to this standard. However, the parties who reach an agreement based on this standard are encouraged to study whether the latest versions of these documents can be used. For all undated references, the latest versions apply to this standard.
GB/T16180
3 Diagnostic principles
Identification of the degree of disability caused by work-related injuries and occupational diseases of employees Diagnostic criteria for occupational acute chemical poisoning of nervous system diseases Based on the occupational history of long-term exposure to n-hexane, the clinical manifestations mainly characterized by multiple peripheral nerve damage appear, combined with laboratory tests and workplace hygiene surveys, comprehensive analysis, and exclusion of similar diseases caused by other reasons, a diagnosis can be made. 4 Observation subjects
After long-term exposure to n-hexane, there is no sign of peripheral nerve damage, but there is one of the following: a)
Numbness and pain in the distal limbs, heaviness in the lower limbs, which may be accompanied by cold hands and feet, sweating, loss of appetite, weight loss, dizziness, headache, etc.;
b) Neuro-electromyography shows suspected neurogenic damage. 5 Diagnosis and classification standards
Mild poisoning
The above symptoms are aggravated, and there is one of the following: a) Symmetrical pain, touch or sound and vibration disorders appear in the distal limbs, accompanied by weakened Achilles tendon reflex; neuro-electromyography shows definite neurogenic damage. b)
5.2 Moderate poisoning
On the basis of mild poisoning, one of the following conditions exists: disappearance of Achilles tendon reflex;
b) lower limb muscle strength 4 degrees;
neuro-EMG shows neurogenic damage and more spontaneous denervation potentialsc
5.3 Severe poisoning
On the basis of moderate poisoning, one of the following conditions exists:a) lower limb muscle strength 3 degrees or less;
b) obvious atrophy of distal muscles of the limbs and affecting motor functionHandling principleswwW.bzxz.Net
Treatment principles
6.1.1 Disengagement;
6.1.2 Integrated Chinese and Western medicine treatment, supplemented by acupuncture, physical therapy and limb motor function training, etc. 2 Other treatments
Mildly poisoned patients can return to their original jobs after recovery. Moderate and severe patients should not engage in work involving n-hexane or other work that may cause peripheral nerve damage after recovery. If labor capacity assessment is required, it shall be handled in accordance with GB/T16180. Instructions for the correct use of this standard
See Appendix A (Informative Appendix).
Appendix A
(Informative Appendix)
Instructions for the correct use of this standard
A.1 This standard applies to the diagnosis and treatment of chronic poisoning cases caused by long-term exposure to n-hexane in occupational activities. Non-occupational chronic n-hexane poisoning can also be implemented as a reference. A.2 Polyneuropathy is the clinical feature and diagnostic starting point of this disease. The diagnosis of polyneuropathy is based on bilateral symmetrical paresthesia or sensory impairment with the distal extremities as the main feature, lower motor neuron dyskinesia, and changes in neurogenic damage in the neuro-electromyogram. The classification of its diagnosis is based on the degree of peripheral nerve damage. A.3 The muscle strength examination methods and classification principles mentioned in the diagnostic classification standards shall be implemented in accordance with Appendix C "Muscle Strength Classification Standards" in GBZ76.
A.4 The electromyography examination methods and the judgment criteria for abnormal results mentioned in the diagnostic classification standards shall be implemented in accordance with Appendix B.1 and B.2 in GBZ76.
A.5 The subjects have early symptoms of peripheral nerve damage but no clear signs, or the neuro-electromyography only shows suspected neurogenic damage, so they are not classified as poisoning. However, because some of the subjects are actually patients with chronic n-hexane poisoning in the incubation period, the incubation period can be as long as 3 months, so the subjects should be separated from contact and undergo 3 months of observation. During the observation period, pay attention to possible peripheral nerve damage. If there is no evidence of peripheral nerve damage during the 3-month observation period, chronic n-hexane poisoning can be ruled out. A.6 Urinary 2,5-hexanedione is only an indicator of recent n-hexane exposure and is not related to the clinical manifestations of chronic n-hexane poisoning, so it is not listed as a diagnostic indicator.
A.7 Comprehensive treatment should be used for the treatment of chronic n-hexane poisoning, including separation from exposure, ensuring adequate nutrition for the patient, administration of B vitamins, energy mixtures, Chinese medicines for promoting blood circulation and removing blood stasis, promoting collaterals and tonifying the kidney, as well as acupuncture, physical therapy, and limb motor function exercises.
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