This standard specifies the diagnostic criteria and treatment principles for occupational acute carbon tetrachloride poisoning. This standard applies to the diagnosis and treatment of occupational acute carbon tetrachloride poisoning, and can be used as a reference for non-occupational acute poisoning. GBZ 42-2002 Occupational Acute Carbon Tetrachloride Poisoning Diagnostic Criteria GBZ42-2002 Standard download decompression password: www.bzxz.net

1Cs13.100
National Occupational Health Standard of the People's Republic of China GBZ42—2002
Diagnostic Criteria of Occupational Acute Carbon Tetrachloride Poisoning2002-04-08 Issued
Ministry of Health of the People's Republic of China
Implementation on 2002-06-01
Article 6.1 of this standard is recommended, and the rest are mandatory. This standard is formulated in accordance with the "Law of the People's Republic of China on the Prevention and Control of Occupational Diseases". From the date of implementation of this standard, if the original standard GB11509-1989 is inconsistent with this standard, this standard shall prevail. Acute carbon tetrachloride poisoning may occur in occupational activities involving exposure to carbon tetrachloride. In order to protect the health of the exposed persons, facilitate the prevention and control of poisoning, and in accordance with the requirement that the diagnostic standards for occupational diseases should reflect the latest clinical progress, GB11509-1989 has been revised.
The GB11509-1989 version of this standard specifies the diagnostic criteria and treatment principles for occupational acute carbon tetrachloride poisoning. This revision reviewed the relevant clinical literature at home and abroad in the past nine years. The results show that the diagnostic and treatment principles of the original standard are clear and concise, in line with clinical practice, and can continue to be used in principle. In recent years, the state has promulgated and implemented a series of standards of general nature for acute chemical poisoning. According to the principle that the manifestations of target organ damage of occupational diseases are identical, the relevant contents of the original standard involving damage to the nervous system, liver and kidneys can be implemented by referring to the relevant provisions in the relevant general standards. The appendix of this standard adds an explanation of the relationship between this standard and the relevant general standards.
Appendix A of this standard is an informative appendix.
This standard is proposed and managed by the Ministry of Health of the People's Republic of China. This standard was drafted by the Guangdong Provincial Institute of Occupational Disease Prevention and Control, and the participating units include the School of Public Health of Sun Yat-sen University of Medical Sciences, Chongqing Guanyuan Chemical Plant Staff Hospital and Henan Provincial Institute of Occupational Disease Prevention and Control. This standard is interpreted by the Ministry of Health of the People's Republic of China. Occupational acute carbon tetrachloride poisoning diagnostic standard GBZ42-2002
Occupational acute carbon tetrachloride poisoning is a systemic disease caused by short-term exposure to high concentrations of carbon tetrachloride during occupational activities, with damage to the nervous system and (or) liver and kidney as the main symptoms. 1 Scope
This standard specifies the diagnostic standard and treatment principles for occupational acute carbon tetrachloride poisoning. This standard applies to the diagnosis and treatment of occupational acute carbon tetrachloride poisoning, and can be used as a reference for non-occupational acute poisoning. 2 Normative references
The clauses in the following documents become the clauses of this standard through reference in this standard. For all dated referenced documents, all subsequent amendments (excluding errata) or revisions are not applicable to this standard. However, the parties to the agreement based on this standard are encouraged to study whether the latest versions of these documents can be used. For all undated referenced documents, the latest versions shall apply to this standard.
GB/T16180
3 Diagnostic principles
Diagnostic criteria for occupational toxic liver disease
Diagnostic criteria for occupational acute chemical toxicity of nervous system diseasesDiagnostic criteria for occupational acute toxic nephropathyIdentification of the degree of disability caused by work-related injuries and occupational diseases of workersAccording to the occupational history of short-term exposure to high concentrations of carbon tetrachloride, the clinical manifestations of central nervous system and (or), liver and kidney damage appear quickly, combined with laboratory tests and on-site labor hygiene survey data for comprehensive analysis, and after excluding similar diseases caused by other causes, a diagnosis can be made.
4 Contact reactions
Those who experience transient dizziness, headache, fatigue, or irritation of the eyes and upper respiratory tract mucosa after exposure to carbon tetrachloride.
5 Diagnosis and classification standards
5.1 Mild poisoning
In addition to dizziness, headache, fatigue, or irritation of the eyes and upper respiratory tract mucosa, the patient also has one of the following manifestations: a) gait or mild disturbance of consciousness;
b) liver enlargement, tenderness and mild liver function abnormality; c) proteinuria, or hematuria and tubular urine.
5.2 Severe poisoning
The above symptoms are aggravated, and the patient also has one of the following manifestations: a) coma;
b) severe toxic liver disease;
c) severe toxic nephropathy.
Treatment principles
Treatment principles
6.1.1 Immediately leave the scene, treat according to general first aid routine, and give oxygen early. The poisoned person should rest in bed, be closely observed, and be given a high-calorie, high-vitamin and low-fat diet. 6.1.2
There is no specific antidote at present. In the early stage, the main treatment is to actively prevent and treat the damage of the nervous system, liver and kidney. 6.1.3
6.2 Other treatments
The mildly poisoned can resume their original work after recovery. 6.2.1
6.2.2 After the severe poisoning is cured, it can be arranged to work without contact with poisons according to the recovery of the disease. Those who need to be assessed for their ability to work shall be handled in accordance with GB/T16180.
Instructions for the correct use of this standard
See Appendix A (Informative Appendix). bzxZ.net
Appendix A
(Informative Appendix)
Instructions for the correct use of this standard
A.1 This standard applies to occupational acute carbon tetrachloride poisoning. Non-occupational acute carbon tetrachloride poisoning can also be used as a reference. A.2 Carbon tetrachloride can decompose into harmful gases such as phosgene when heated. Therefore, when carbon tetrachloride is heated (such as when using a fire extinguisher containing carbon tetrachloride), if respiratory symptoms occur, phosgene poisoning should be considered. A.3 Those who have been exposed should generally be observed for 7-10 days, and pay attention to early signs of damage to the nervous system, liver and kidneys. A.4 According to clinical practice and animal experimental data, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are still used as the main diagnostic indicators for liver damage caused by acute carbon tetrachloride poisoning in China. Other liver function tests such as serum total bile acid (TBA), serum glycocholic acid (CG), adenosine deaminase (ADA), and prealbumin (PA) can also be used for auxiliary diagnosis.
A.5 Those who die from exposure to extremely high doses of carbon tetrachloride in a short period of time may not have obvious liver and kidney damage. A.6 The diagnosis and treatment principles and nursing methods for the disturbance of consciousness, liver and kidney function mentioned in the diagnostic classification standard should be implemented in accordance with the relevant standards (GBZ76; GBZ59 and GBZ79). A.7 Treatment
Acetylcysteine ​​and glutathione have certain effects. Blood purification therapy is suitable for severe cases, and hyperbaric oxygen therapy can also be considered.
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