Some standard content:
GB8982-1998
Foreword
This standard is a revision of GB8982-1988 "Medical Oxygen" and GB/T8986-1988 "Test Methods for Medical and Aviation Breathing Oxygen".
This revision retains the main relevant technical contents of GB8982-1988 and GB/T8986--1988, but adds liquid oxygen to the scope of application, and adds technical contents such as sampling, packaging, storage and transportation of liquid oxygen; the expression of water content in technical requirements is changed to dew point; in the determination of gaseous acids and alkalis, the indicator liquid is increased to a mixture of methyl red and bromovanillin blue. This standard is equivalent to IOCT5583-1978 "Technical Conditions for Industrial and Medical Gaseous Oxygen". This standard replaces GB8982-1988 and GB/T8986-1988 from the date of implementation. Appendix A of this standard is the standard appendix, and Appendix B is the prompt appendix. This standard is proposed by the Ministry of Chemical Industry of the People's Republic of China. This standard is under the jurisdiction of the Southwest Research Institute of Chemical Industry of the Ministry of Chemical Industry. The drafting units of this standard are: Southwest Research Institute of Chemical Industry of the Ministry of Chemical Industry, Chengdu Aviation Station General Plant No. 4, and West China University of Medical Sciences. The main drafters of this standard are: Zhou Eyun and Wang Xiaoou. 726
Scope11
National Standard of the People's Republic of China
Medical
Oxygen
Oxygen supplies for medicineGB 8982—1998
Replaces GB8982—1988
GB/T 8986--1988
This standard specifies the technical requirements, test methods, packaging, marking, etc. of medical oxygen products. This standard applies to gaseous oxygen and liquid oxygen prepared by cryogenic separation of air, mainly used for respiratory and medical purposes. Molecular formula: 02
Relative molecular mass: 31.999 (according to the 1995 international relative atomic mass) 2 Reference standards
The provisions contained in the following standards constitute the provisions of this standard through reference in this standard. When this standard is published, the versions shown are valid. All standards will be revised, and the parties using this standard should explore the possibility of using the latest versions of the following standards. GB190--1990 Dangerous Goods Packaging Marking GB5099-1994 Seamless Steel Gas Cylinders
GB/T5832.2--1986 Determination of Trace Moisture in Gases-Dew Point Method GB/T6681-1986 General Rules for Sampling of Gas Chemical Products GB/T6682--1992
Specifications and Test Methods for Water Used in Analytical Laboratories (eqvISO3696:1987) GB7144-1986 Color Marking of Gas Cylinders
GB 11640-1989
GB 14193-1993
GB 14194-1993
Aluminum Alloy Seamless Gas Cylinders
Regulations for Filling Liquefied Gas Cylinders
Regulations for Filling Permanent Gas Cylinders
GB/T 14953-1994
GB 50030
—1991
JB 6897--1993
JB 6898-1993
3 Requirements
Pure copper wire
Design specification for oxygen stations
Cryogenic liquid tanker
Cryogenic liquid storage equipment
Safety specification for use
Oxygen produced by cryogenic distillation is prohibited from use if it is subsequently compressed in a compressor with piston seals made of fluoroplastics or other materials that have not been inspected and qualified by the medical supervision department. The technical indicators of medical oxygen should meet the requirements of Table 1. 21 Instructions for use:
1] Liquid oxygen is added.
2] Water content is expressed by eel point.
Approved by the State Administration of Quality and Technical Supervision on October 19, 1998, and implemented on April 1, 1999
727
Oxygen content, 10-2, V/V
Moisture content (dew point), C
Carbon dioxide content
. Carbon oxide content
Item
Content of gaseous acidic and alkaline substances
Ozone and other gaseous oxides
Odor
Note: There is no specified moisture index for liquid oxygen.
4
Inspection rules 1
Item
GB 8982 --1998
Table 1
Technical indicators
Standard
Indicator
99.5
43
Qualified by the specified method
Qualified by the specified method
Qualified by the specified method
Qualified by the specified method
Qualified by the specified method
No odor
4.1 Medical oxygen shall be inspected by the quality inspection department of the manufacturer. The manufacturer shall ensure that all medical oxygen leaving the factory is qualified. 4.2 Bottled medical oxygen shall be sampled in batches. One batch is a batch of products produced continuously by 2 operating shifts. Randomly select 2% of the samples from each batch for inspection. When the batch is less than 100 bottles, the number of samples shall not be less than 2 bottles; when it is more than 200 bottles, the number of samples shall not be less than 5 bottles. When one bottle fails to meet any requirement of this standard in the test results, the same batch of products shall be re-sampled and re-tested. If any index still fails to meet the requirements of this standard in the re-test results, the batch of products shall be unqualified. 4.3 Liquid oxygen is sampled from the liquid phase of each filling container and tested after evaporation into gaseous state. If one index of the test results fails to meet the requirements of this standard, the product shall be unqualified.
4.4 When the user and the manufacturer have different opinions on the quality of the product, both parties shall conduct a joint inspection or apply for arbitration. 5 Test method
5.1 Determination of oxygen content
5.1.1 Method and principle
The oxygen content is determined by the copper ammonia solution absorption method. Take 100mL of sample gas and contact it with the absorption liquid in the absorption bottle. Oxygen is absorbed through reaction and the oxygen content is determined based on the reduction in the volume of the sample gas. 5.1.2 Reagents and materials
Ammonium fluoride: analytically pure;
Ammonia water: analytically pure. 25.0×10~2~~28.0×10-2 (m/m) aqueous solution; Distilled water: The water used in this test method meets the requirements of GB/T6682 Grade 3 water: Mixed solution: Dissolve 600g of ammonium fluoride in 1000ml. Distilled water, add 1000mL of ammonia water, and mix well; Vacuum piston grease;
Copper wire ring: Use T2 copper wire with a diameter of 1mm that meets the requirements of GB/T14953, wind it around a rod with a diameter of 5mm, then remove it and cut it into small pieces of 10mm long.
5.1.3 Instruments
The oxygen analyzer is shown in Figure 1, and the processing diagram of the gas measuring tube and absorption bottle is shown in Appendix B (Reminder Appendix). 5.1.4 Preparation
Connect the components of the oxygen analyzer as shown in Figure 1 with rubber hoses, and apply vacuum piston grease to the three-way piston. Fill the absorption bottle with copper wire ring. Pour the mixed liquid into the level bottle, turn the three-way piston to connect the gas measuring tube with the absorption bottle, and use the level bottle to increase the content of liquid oxygen, but do not use the content of pipeline oxygen. 2
GB. 8982 -- 1998
Lift and lower the gas measuring tube, capillary tube, absorption bottle and all pipelines to fill the mixed liquid, and a total of about 550ml of mixed liquid is required. Adjust the liquid level in the liquid seal bottle to an appropriate position. Close the piston and lower the level bottle. If the liquid level in the gas measuring tube does not decrease, it means that the instrument is not leaking. 5.1.5 Measurement
Turn the three-way piston to connect it with the absorption bottle, lower the level bottle, and guide the residual gas in the absorption bottle into the gas measuring tube. 3
nk
N
4
5
88888881
1-Gas measuring tube: 2-three-way piston; 3-connecting tube; 4-capillary tube; 5-absorption bottle; 6-liquid seal bottle: 7-water push bottle Figure 1
Turn the three-way piston to connect the gas measuring tube to the atmosphere, raise the level bottle, and fill the top of the piston branch with liquid. Close the three-way piston. Sampling is carried out from the oxygen cylinder through a pressure reducing valve connected to a rubber hose. Sampling should comply with the provisions of GB6681. First, use a large airflow to blow off the valve and pipeline 0.5 minutes, then adjust to the flow rate required for analysis and purge for 1 minute. Connect the rubber tube that carries the sample gas to the three-way piston branch. Quickly open the three-way piston so that the sample gas slightly exceeds the zero mark of the measuring tube. Immediately press the rubber tube connecting the level bottle and the measuring tube with your fingers, and quickly remove the sample. Use rubber hose. Align the liquid level of the level bottle with the zero mark of the gas pipe, and slightly loosen the tight rubber tube until the liquid level in the gas pipe reaches the zero mark and then tighten it again. Turn the three-way piston to connect the measuring tube and the absorption bottle. Slowly lift the level bottle so that all the gas samples enter the absorption bottle. Close the three-way piston. Shake the instrument carefully and fully for 3 minutes, open the three-way piston, and slowly return the gas to the measuring tube. When the absorbing liquid first enters the measuring tube, close the piston, and lift the level bottle so that its liquid level matches the liquid level in the measuring tube. Align, then the corresponding scale of the liquid level in the measuring tube is the volume percentage of oxygen in the sample.
Let the unabsorbed gas in the measuring tube enter the absorption bottle again for reabsorption until the difference between two consecutive analysis results does not exceed 0.05%.
Note
1 Always pay attention to filling the copper wire circumference so that the sample gas is fully in contact with the copper wire. 2. The absorbing liquid will become invalid after absorbing dozens of sample gases. It should be replaced when it first turns yellow. When replacing, about one-fifth of the solution should be retained. 5.1.6 Result processing
The difference between the two measurement results of the same sample should not exceed 0.05%, and the arithmetic mean is the final measurement result. 5.2 Determination of water content 1?
Adoption instructions:
1 only uses the dew point method.
729
Measured according to the provisions of GB/T5832.2. 5.3 Determination of carbon dioxide
5.3.1 Reagents and solutions
GB 8982—1998
Barium hydroxide: analytical grade, 5×10?2 (m/m) aqueous solution (absorption liquid ). Dissolve 5g barium hydroxide in 100mL water, quickly filter the solution with dense filter paper, and store it in a bottle sealed with a stopper. The stopper is inserted into a glass tube, and the other end is connected to a bottle containing sodium hydroxide or potassium hydroxide solution. connect.
Distilled or deionized water: In order to remove carbon dioxide, boil the water for 30 minutes until large bubbles are released. During cooling and storage, the water should be protected from contamination by carbon dioxide contained in the atmosphere. Sodium hydroxide or potassium hydroxide: analytical grade, 2×10-1 (m/m) aqueous solution. Sodium bicarbonate: analytical grade, 4×10-* (m/m) aqueous solution. Prepared by dissolving 0.04g sodium bicarbonate in 100mL water. 5.3.2 Instruments
Graduation pipette: capacity 1ml.;
Monteggia gas washing bottle: rated capacity 100mL; gas flow meter;
Measurement summary: capacity 100mL.
5.3.3 Preparation
Connect the medical oxygen cylinder with the pressure reducing valve to the gas washing bottle and the gas flow meter. Blow out the wash bottle with the analyzed oxygen for 1~~~2 minutes. 5.3.4 Set
to inject 100mL of clear hydroxide lock solution into the gas washing bottle. Within 15 to 20 minutes, let 1000mL of oxygen pass through the absorption liquid. Add 1 mL of sodium bicarbonate solution to a gas washing bottle containing 100 mL of barium hydroxide solution to prepare a standard bicarbonate solution. Use visual colorimetry to compare the absorbent solution with the standard comparison solution. If the turbidity of the absorption liquid after passing through oxygen is not stronger than the turbidity of the standard turbidity solution, it is considered that the carbon dioxide content in the medical oxygen meets the requirements. 5.4 Determination of carbon monoxide
5.4.1 Reagents and solutions
Ammonia: analytical grade, 1×10-(m/m) aqueous solution: distilled or deionized water;
Silver nitrate: Analytically pure, 5×10-2 (m/m) nitrogen solution. Dissolve 5g of silver nitrate in 100mL of water. Add human ammonia solution dropwise to the solution with constant stirring until the residue is no longer dissolved. After filtering the solution, seal it in a dark glass bottle and store it away from light. 5.4.2 Instruments
are recommended according to the provisions of 5.3.2.
5.4.3 Preparation work
shall be carried out in accordance with the provisions of 5.3.3.
5.4.4 Determination
Within 30 to 35 minutes, let 2000mL of oxygen pass through the washing bottle containing 100mL of hot silver nitrate ammonia solution. Observe the color of the solution. If it is still colorless and transparent, it means that the analysis sample does not contain carbon monoxide. 5.5 Determination of gaseous acid and alkali content
5.5.1 Reagents and solutions
Distilled or deionized water;
Hydrochloric acid: analytical grade, 0.01mol/1. solution; instructions for use :
1] Added the bromovanillin blue indicator method. 730
60% absolute ethanol solution;
20% absolute ethanol solution;
GB 8982—1998
methyl red indicator: 0.2% Anhydrous ethanol solution. Prepared by dissolving 0.2g methyl red in 100mL absolute ethanol (60%); bromomethol blue indicator: 0.1% alcohol solution. It is prepared by dissolving 0.1g bromovanillin blue in 100mL absolute ethanol (20%) solution.
Instruments
5.5.2
Prepare according to the provisions of 5.3.2.
5.5.3 Preparation work
shall be carried out in accordance with the provisions of 5.3.3.
5.5.4 Determination
5.5.4.1 Methyl red indicator method
Inject 100mL of water into each of the three numbered gas washing bottles. Add 4 to 6 drops of methyl red solution to each bottle. Use a pipette to add 0.2 mL hydrochloric acid solution to bottle No. 2, and add 0.4 mL hydrochloric acid solution to bottle No. 3. Within 30 to 35 minutes, allow 2000 mL of oxygen to pass through the solution in bottle No. 2. Compare the color of the solution in bottle 2 with the colors of the solutions in bottles 1 and 3. If the color of the solution in bottle No. 2 is different from the yellow color of the solution in bottle No. 1 but pink, the gaseous alkali content in the medical oxygen is considered to meet the requirements. If the pink color of the solution in bottle No. 2 is lighter than the pink color of the solution in bottle No. 3 color, it is considered that the gaseous acid content in oxygen meets the requirements. 5.5.4.2 Mixed indicator method of methyl red and bromothymol blue. Take 0.3 mL each of methyl red indicator solution and bromothymol blue indicator solution, add 400 mL distilled water, boil for 5 minutes, and let cool. Inject 100mL of the cooled solution into each of the three numbered gas washing bottles. Use a pipette to add 0.2 mL hydrochloric acid solution to bottle No. 2, and add 0.4 mL hydrochloric acid solution to bottle No. 3. Within 30 to 35 minutes, allow 2000 mL of oxygen to pass through the solution in bottle No. 2. Compare the color of the solution in bottle 2 with the colors of the solutions in bottles 1 and 3. If the color of the solution in bottle No. 2 is not darker than the green color of the solution in bottle No. 1, it is considered that the gaseous alkali content in medical oxygen meets the requirements; if the color of the solution in bottle No. 2 is lighter than the red color of the solution in bottle No. 3, it is considered that The gaseous acid content in oxygen meets the requirements. Both methods are equally effective.
5.6 Determination of ozone and other gaseous oxide content 5.6.1 Reagents and solutions
Distilled or deionized water;
Potassium iodide: analytical grade;
Soluble starch: Analytical grade;
Mixture of starch and potassium iodide: Dissolve 0.5g potassium iodide in 95mL heated water, then mix 0.5g starch with 5mL cold water, and slowly pour the mixture into boiling potassium iodide while stirring In the solution, cook for 2 to 3 minutes: Acetic acid: analytically pure.
5.6.2 Instruments
Prepare according to the provisions of 5.3.2;
5.6.3 Preparation work
Carry out according to the provisions of 5.3.3.
5.6.4 Determination
Inject 100mL of the newly prepared mixed solution of starch and potassium iodide into the gas washing bottle, and add a drop of acetic acid. Let 2000mL of oxygen pass through the gas scrubbing bottle within 30~35 minutes. Observe the solution in the washing bottle. If it remains colorless, it means that the sample being analyzed does not contain ozone and other gaseous oxidants, and the oxygen is considered to meet the requirements of 731
.
5.7 Determination of odor
GB8982 - 1998
Determination of odor through sensory organs. Open the bottle valve slightly and if the oxygen flowing out has no peculiar smell, the product is considered to meet the requirements. 6 Packaging, marking, safety 1
6.1 Packaging containers
Cylinders for filling and storing gaseous oxygen should comply with the regulations of GB5099 and GB11640. Containers for filling, storing and transporting liquid oxygen should comply with the "Pressure Vessel Safety Technical Supervision Regulations" and JB6897. Before leaving the factory, bottled oxygen should be checked for leaks at the bottle mouth, the threaded connection of the bottle valve, and the bottle valve stem, and the bottle cap and anti-vibration ring should be put on. 6.2 Filling
6.2.1 Gaseous oxygen
Gaseous oxygen filling should comply with the regulations of GB14194. Cylinders filled with medical oxygen need to be heated and evacuated after the first filling or hydrostatic test.
After confirming that the oxygen temperature in the cylinder is equal to the ambient temperature, measure the gas pressure with a pressure gauge not lower than level 2.5. The filling pressure should be (15.0±0.5) MPa at 20C. At 20°C and 101.3kPa, the volume Vz (m\) of gaseous oxygen in the cylinder is calculated according to formula (1): V=K×V3
-oxygen volume conversion coefficient, see Appendix A (standard Appendix); where: K——i
V3——water volume of oxygen cylinder, L.
6.2.2 Liquid oxygen
Liquid oxygen filling should comply with the regulations of GB14193. The mass of liquid oxygen is converted to the volume of gaseous oxygen at 20°C and 101.3kPa, V, (m\), calculated according to formula (2): V = m ——The mass of liquid oxygen, t, 1.331 ——The density of oxygen, kg/m.
6.3 Marks
The steel stamp mark of oxygen cylinders shall comply with the provisions of the "Gas Cylinder Safety Supervision Regulations". The paint color marking of oxygen cylinders should comply with the regulations of GB7144. Oxygen cylinder transportation safety signs should comply with the regulations of GB190. Containers packaging medical oxygen should be marked with the words "Medical Oxygen" in black. 6.4 Safety
6.4.1 The safe use, transportation and storage of oxygen cylinders should comply with the provisions of the "Gas Cylinder Safety Supervision Regulations". The safe use of cryogenic liquid storage equipment should comply with the regulations of JB6898. ....(1)
*(2)
6.4.2 Oxygen is a colorless, odorless, filmless, non-toxic, non-flammable gas. It is a strong oxidant that can support combustion and store oxygen. It is strictly prohibited to store strongly reducing gases, such as hydrogen, in the gas cylinder warehouse. During storage, oxygen should be isolated from other dangerous gases and corrosive substances. 6.4.3 The warehouse where oxygen bottles are stored should be kept away from heat and fire sources, and away from living areas where residents are concentrated. The distance between the warehouse and related buildings should comply with the regulations of GB50030. The floor, roof, and surrounding walls of the warehouse are made of materials with good flame retardant effects and are equipped with good ventilation facilities.
6.4.4 Before overhauling and processing oxygen-containing containers, all internal spaces must be purged with clean air or nitrogen. Only when the volume concentration of oxygen in the container drops below 23X10-2, work is allowed to start. 6.4.5 Containers containing medical oxygen are prohibited from being used to fill other gases, and it is prohibited to carry out activities that may contaminate its inner surface and damage the physical and chemical properties of the product. Instructions for use:
1 Added liquid oxygen, and no storage and transportation methods are used. Gas pressure data table in the cylinder 4. 732
any operation of chemical indicators.
GB8982—1998
6.4.6
5 In an oxygen-rich environment (oxygen content ≥23×10-2), open flames are not allowed. 6.5 Certificate
When medical oxygen leaves the factory, it should be accompanied by a quality certificate, which includes: product name; name of manufacturer: production date and production batch number: oxygen quantity (m\), pressure (MPa) or quality (kg); code number of this standard. 733
Temperature, ℃
- 50
-40
-35
30
25
20|| tt||15
10
-5
0
+5
+10
+15
+ 20
+25
+30
+35
+40
+50
734
14.0|| tt||0.232
0.212
0.203
0.195
0.188
0.182
0.176
0.171||tt| |0.165
0.161
0.157
0.153
0.149
0.145
0.142
0.139
0.136
0.133
0.127bZxz.net
14.5
0.242
0.221
0.211
0.202
0.195|| tt||0.188
0.182
0.177
0.172
0.167
0.162
0.158
0.154||tt| |0.150
0.147
0.143
0.140
0.137
0.132
15.0
0.251
0.229
0.219
0. 211
0.202
0.195
0.189
0.183
0.178
0.172
0.168
0.163
0.159
0.156
0.152
0.148
0.145
0.142|| tt||0.136
GB 8982 — 1998
Appendix A
(standard appendix)
Oxygen volume conversion coefficient K
Pressure, MPa|| tt||15.5
0.260
0.236
0.226
0.217
0.209
0. 202
0.196|| tt||0.189
0.184
0.179
0.174
0.169
0.165
0.160
0.157||tt| |0.153
0.150
0.147
0.141
16.0
0.269
0.245
0.234
0.225
0.217
0.209
0.202
0.195
0.190
0.184
0.179
0.174|| tt||0.170
0.166
0.162
0.158
0.154
0.151
0.145
16.5||tt| |0.278
0.253
0.242
0.232
0.223
0.215
0.208
0.202
0.195
0.190
0.185
0.180
0.175
0.171
0.167
0.163
0.159|| tt||0.156
0.149
17.0
0.286
0.260
0.249
0.239
0.230||tt| |0.222
0.215
0.208
0.202
0.196
0.190
0.185
0.180
0.176
0.172
0.168
0.164
0.160
0.154
17.5
0.296
0.269|| tt||0.257
0.248
0.238
0.229
0.221
0.214
0.207
0. 201
0.196
0.191
0.186
0.181
0.177
0.173
0.169
0.165| |tt||0.158
18.0
0.303
0.275
0.264
0.253
0.243
0.235||tt ||0.227
0.220
0.213
0.207
0.201
0.196
0.191
0.186
0.182
0.177
0.173
0.170
0.163
Tip: This standard content only shows part of the intercepted content of the complete standard. If you need the complete standard, please go to the top to download the complete standard document for free.