This standard specifies the requirements, testing and inspection rules for toxic dangerous goods. This standard applies to the inspection of hazardous properties and applicable packaging categories of toxic dangerous goods. GB 19521.7-2004 Safety specification for inspection of hazardous properties of toxic dangerous goods GB19521.7-2004 Standard download decompression password: www.bzxz.net

ICS 13. 300
National Standard of the People's Republic of China
CGB19521,72004
Safety code for inspection of hazardous properties of toxic and dangerous goods loxic:subsiantes2004-05-20 Issued
General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China Standardization Administration of China
2004-1T-01 Implementation
Chapter 4 and Chapter 5 of this standard are mandatory, and the rest are recommended GB19521.7-2D04
This standard is not equivalent to the United Nations Standardized Recommendations on the Transport of Goods (Model Regulations for the Inspection of Goods Transport) (Part 1) and its relevant technical contents are the same as those in the above chapters. The standard submission format has been revised according to GH/T1.1-2000. This standard is a national hazardous chemical The standard was proposed and coordinated by Shenzhen Standardization Technical Committee (SAC/TC251). The responsible drafting unit of this standard is the Dangerous Goods Laboratory of the Institute of Quality Supervision, Inspection and Quarantine of the State Administration of Quality Supervision, Inspection and Quarantine, and the participating drafting units of this standard are the Tianshan Entry Control and Quarantine Bureau, the Asia-Pacific Dangerous Goods Association, and the University of Science and Technology of China: Technical Standard Feng'an Initiators: Gan Caibing, Liu Shaocong, Zhang Yuan, Gao Jian, Ma Jun, and Tong Dangjie. This standard is formulated for the first time
1 Scope
Safety specification for inspection of hazardous properties of toxic hazardous goods This standard specifies the requirements, tests and inspection rules for toxic dangerous goods. This standard applies to the inspection of hazardous properties of reproducible dangerous goods and applicable other packaging categories: 2 Normative references
CB 19521.7—2004
The following are the references to this standard. For documents with a date, all subsequent amendments (excluding the contents of the document) shall not apply to this standard. However, the parties who have reached an agreement based on this standard shall consider whether the newest versions of these documents can be used. For documents without a date, the newest versions shall apply to this standard. 15193.3—1991 Acute test
GH1548 Safety specification for inspection of hazardous properties of hazardous goods GB19521.8 Safety specification for inspection of hazardous properties of gases and other hazardous goods: General regulations on the transport of hazardous goods 3 Terms and definitions
The terms and definitions established in the United Nations Recommendations on the Transport of Dangerous Goods Model Regulations (13th edition) and the following terms and definitions apply to this standard.
Isosorbide-5-Nitrae Toxic Substances
Chemical Substances that may cause death or serious damage to human health by inhalation or skin contact. 3.2
Conceptual Oral Toxicity LD value acleoraltox LD value is the dose of the substance that may cause half of the test animals to die within 1 day after administration. The test results are expressed in mg/g body weight.
Acute Dermal Toxicity LD value acofedcrmallaxicilylus ...
Acute toxicity is the concentration of gas, mist or dust that is most likely to cause half of the test animals to die within 14 days after continuous inhalation for 1 hour.
4 Requirements
4.1 The printed, unprinted or printed marks, signs and color labels of dangerous goods on the packaging of toxic dangerous goods shall be clear and in accordance with the relevant provisions of GB19458-2004.
4.2 Toxic dangerous goods shall not be transported in the same railway freight, car, cabin, aircraft medical cabin or other transport equipment as food, feed and other food for humans or animals. 4.3 Railway trucks, cars, supercars, aircraft cabins and other transport equipment carrying dense and dangerous goods shall be inspected for contamination before reuse. Contaminated railway wagons, cars, ship cabins, aircraft cabins and other transport equipment should not be used again before the contamination is removed. 4.4 Dangerous goods of different types should be stored separately. Goods with different hazard levels and fire retardants should be stored separately. Goods with different properties should not be mixed.
5 Tests
5.1 Oral toxicity test
5.1.1 Test samples
Use water or disinfectant as disinfectant. If the test sample is not dissolved in water or soap, it can be mixed with starch in a bottle at night to make a dose. The maximum volume should not exceed 1.4L/3U body weight for mice and 1.0mL/00 body weight for rats. 5.1.2 Test Animals Select mice or rats. Take healthy adult test animals weighing 188-22g and 180g-229g for rats. After entering the test room, there should be 2-5 hours of time for each group. Then randomly assign them to each group. 5.1.3 Test Methods 5. 1.3.1 Dosing and Grouping The test animals are randomly divided into four dose groups, with 10 animals in each group, half of them are male and half are female. The test substance is administered to the animals once a day with a special injection needle. If the test substance is estimated to be very low in potency, the single dose volume can be divided into 2-1 doses within 24 hours, but the single dose volume is not calculated as one day. The formula for determining the dose series is as follows: GB15193.31994, 5.1.3.2 Test steps
Place the animals in the same animal store for 1 hour to 2 days. Allow them to adapt to the environment. After proving that they are healthy animals, they are randomly divided into groups. Use the dose series determined by the method to expose the animals once. Observe for 14 days, record the number of deaths, obtain the L:, and record the time of death and the condition. The P value calculated by the Hom method is shown in Appendix A of GB15193.31994. 5.7. Intended percutaneous toxicity test
5.2.1 Test sample
a! Grind the test sample into powder and add appropriate amount of water or non-toxic and non-irritating excipient liquid to ensure good contact between the test sample and the skin.
[5) If the test article is a liquid, no need for clarification: 5.2.2 Test Animals
Adult domestic rabbits weighing 2.6kg~3.0kg should be placed in the test room for 2-5 days. 5.2.3 Test Methods
5.2.3.1 Preparation and Division
Randomly divide domestic rabbits of both sexes into 5-6 groups. If a liquid drug is used, a liquid drug group should be used. 5.2.3.2 Test Procedures
Special Test Procedures
Clean the back of the animal and cover it with oil paper and two layers of gauze, then fix it with non-irritating cloth or tape: Weakly prevent the animal from eating the drug, and stimulate the drug for 241. Test Results: Remove the residual test article with water or solvent. Observe for 14 days, record the changes in the actual situation, and calculate the L% value by low-density method. 5.3 Inhalation test 5.3.1 Test sample: a) solid substances, if at least 0% of their total mass may be in the form of inhalable powder, i.e., particles with a diameter of 10 m/s, should be subjected to the test; b) liquid substances, if they may generate smoke when transported in sealed containers, should be subjected to the test. 19521.7—2004
) Whether it is a solid substance or a nocturnal substance, the sample prepared for inhalation (calculated by mass> should be within the inhalable range specified above,
5.3.2 Experimental animals
Commonly used experimental animals are rats and mice. There are at least 10 animals in each concentration group. The samples are of equal weight. The experimental animals should be kept away from people and should have 2 days to adapt to the environment after the experimental study. 5.3.3 Experimental methods
5.3.3.1 Dosage and grouping
At least one concentration should be set. Through preliminary experiments, the mass fraction of 1%~.40% of animals should be selected as the low concentration group. The mass fraction of 4-6% of animals should be selected as this concentration The medium concentration group, the mass fraction is 6%-9% and the animal mortality rate is the high concentration group. The test should be carried out according to the maintenance.
5.3.3.2 Test steps
See GR19521.8, calculate the value of 7.%, 5.4 Limit test
5.4.7 Limit test 1
The product is mixed with air and the concentration of the mixture is 100ml./m3. Place 5 tablets and 5 animals (5 animals) in the test gas environment for 3 hours, and then observe for 14 days. If more than 1 mouse die within the observation period of 11 days, it can be inferred that the 1.Cm value of the mixture is equal to or lower than 1000ml./m3, 5.4.2.2 Limit test: Place a sample of the mixture in a stable state with a volume of the same as that of the mixture in the test gas environment. Place 10 rats (5 males and 5 females) in the test gas environment and observe for 14 days. If more than 5 rats die within the observation period of 14 days, it can be presumed that the volatility of the mixture is equal to or greater than the concentration of the mixture. 5.4.3 Extreme test: Place the sample in a vapor state and dilute it with the test gas to produce a test gas environment with a vapor volatility of 3C50mJm. 10 rats (5 males and 5 females) are placed in the test gas environment for 1 hour and then observed for 14 days. If more than 5 rats die within the 14-day observation period, it can be presumed that the LC value of the compound is equal to or lower than 300mL/m5.4.4 Limit test 4
A vapor sample that is in a state of equilibrium with the liquid compound at 20°C is placed in a test gas environment. 10 rats (5 females) are placed in the test gas environment for 1 hour and then observed for 14 days. If more than 5 rats die within the 14-day observation period, it can be presumed that the volatility of the mixture is equal to or greater than the LC value of the compound. 4.5 Limit test 5
Release the mixture sample into vapor and use a gasifier to reduce the concentration of the mixture vapor: create a test gas atmosphere with a concentration of 53mLm of the mixture vapor, expose 100 mice (5 males and 5 females) to the test gas environment for 1 hour, and then observe for 14 days. If more than 5 mice self-destruct during the 4-day observation period, it can be inferred that the concentration of the mixture is equal to or less than 5000/㎡. 5.4.6 Limit test 6
Resistance to liquid mixture vapor If the benzene concentration is equal to or greater than 0.0001 T/m, it can be inferred that the volatility of the compound is 10 or greater than the mixed LC value 1/5.
5.5 Special determination
5.5.1 Determination of hazard categories and packaging classifications for pure idiosyncratic toxic dangerous goods 5.5.1. Determination of the hazard categories and packaging classifications for each idiosyncratic toxic dangerous goods based on the results of the flash hazard test in Sections 5.1, 5.2 and 5.6 of this standard.
GB 19521.7—2D04
Packing line
Table 1 Acute toxicity test results and packaging categories Acute air toxicity test
Iw(mg/kg)
LDs: su
Solid: 50-30C
Limited body, 50-LD52000
Total toxicity test
ED(mg/k)
40-1,2)
200LD- C0C
5.5.1.2 The results of toxicity test show that the gaseous substance that is not suitable for Class IV packaging should be classified into Class II packaging. The acute inhalation toxicity test
1.Ji;(mg/ky)
D.GLD.S.2
5.5.1.3 If it meets the Class 8 corrosiveness standard and the dust and environmental toxicity (1.Cs0>2) is suitable for Class T packaging, when the results of acute inhalation or acute percutaneous toxicity test are Class 1 or Class 1 packaging, the substance shall be classified into Class 6.1, otherwise it shall be classified into Class 8. 5.5.1.4 Liquids with toxic vapors shall be classified into the following packaging categories, where * is the saturated vapor at 21°C and standard atmospheric pressure. Gas concentration, expressed as the number of condensates per cubic meter of air: Packing group X (e.g., C10LC and 110m1/m2); Packing group 0 (e.g., LC3((0l,/m2);
t)m; Packing group US (e.g., C1/5LC% and tG% 5000mL/m2) 5.5.2 Packing groups for mixtures 5.5.2.1 Packing groups for liquid mixtures with inhalation toxicity 5.5.2.1.1 When the concentration of each volatile substance in the mixture is known, the packing group shall be assigned in accordance with Article 3.6.2.2.4.7 of the Joint Recommendation on the Transport of Dangerous Goods and Specification for the Transport of Dangerous Goods (19th revised edition). 5.5.2.1.2 When the concentration of the volatile substances in the mixture is determined by the technical judgment, the grouping is determined in Table 2. Table 2 1.C value of unknown compound packaging classification classification
Hazard level
Monthly high risk
There is a range of degradation
Use with mild to low risk safety
Rapid test is
Limit test C000
Report limit test.R101.C.
: Limit test 23
Required limit test 4R.C
Suction limit test: 09mL/,
Desorption test control h,Ra1/aiCsr
5.5.2.2 Special classification of compound packaging with oral and percutaneous acute fungibility The classification method of compound packaging with oral and percutaneous acute fungibility is combined with the relevant information on hazardous materials transport. Beijing Standard 43 (13th revised edition) Article 2.6.2.3 6 Inspection rules
6.1 Slow inspection items
Inspect each item one by one according to the requirements of Chapter 4 and Article 5 of this standard. 6.2 Slow inspection items
When any of the following situations occurs, a hazardous characteristic inspection shall be carried out:) When a new product is put into production and the old product is converted into production; h) After formal production, if there are major changes in materials and processes, which may affect product performance: During normal production, once a year; d) After the product is put into production and production is resumed: When there is a large difference between the factory inspection results and the previous hazardous characteristic inspection results; the national quality supervision agency proposes to conduct hazardous characteristic verification. 6.3 Judgment rules
GB 19521.7—2004
Carry out tests in accordance with Sections 5.1 to 5.4 of this technical standard and, based on the test results and the requirements of Section 5.5 of this standard, identify the hazardous characteristics of toxic dangerous goods and their packaging categories.When it is packaged in Class 1 or Class 2, the substance shall be classified in Class 6.1; otherwise, it shall be classified in Class 8. 5.5.1.4 Liquids with toxic vapors shall be classified in the following packing categories, where * is the density of saturated vapor at 21°C and standard atmospheric pressure, expressed as the number of mol/l per cubic meter of air: Class X packing (e.g. c10LC and 110mL/m2); Class 0 packing (e.g. 0LC and LC3 ((0l,/m2;
t)m); US packing (e.g. c1/5LC% and tG% 5000mL/m2); 5.5.2 Classification of mixed packing categories (e.g. tt||); 5.5.2.1 Packing categories of liquid mixtures with inhalation toxicity; 5.5.2.1.1 When the composition is When the 1.C value of each non-toxic substance in a mixture is known, the packing category shall be determined in accordance with Article 3.6.2.2.4.7 of the Joint Recommendation on the Transport of Dangerous Goods (19th revised edition). 5.5.2.1.2 When the 1.C value of a mixture is determined by technical judgment, the classification is shown in Table 2. Table 2 Classification of packing categories for mixtures with unknown 1.C value Packing category High hazard level Some range of hazard level Low hazard level Safety precautions C 000bzxz.net
Report limit test.R101.C.
: limit test 23
Required limit test 4R.C
Inhalation limit test: 09mL/,
Desorption test control h,Ra1/aiCsr
5.5.2.2 Special delineation of packaging for compound products with oral and percutaneous acute fungicide properties The method for delineating the packaging category for compound products with oral and percutaneous acute fungicide properties shall refer to the joint standard for the transport of hazardous substances 43 (13th revised edition)> Article 2.6.2.3 6 Inspection rules
6.1 Slow inspection items
Inspect item by item according to the requirements of Chapter 4 and Article 5 of this standard. 6.2 Light inspection items
When any of the following situations occurs, conduct a risk compliance inspection:) When a new product is put into production and then converted to an old product; h) After formal production, if there are major changes in materials and processes that may affect product performance: During normal production, once a year; d) After product calibration, when production is resumed: When there is a significant difference between the factory inspection results and the previous hazardous characteristics inspection results; the national quality supervision agency proposes to conduct hazardous characteristics verification. 6.3 Judgment rules
GB 19521.7—2004
Conduct tests according to Articles 5.1 to 5.4 of the technical standard, and determine the hazardous characteristics and packaging categories of toxic dangerous goods based on the test results and the requirements of Article 5.5 of this standard.When it is packaged in Class 1 or Class 2, the substance shall be classified in Class 6.1; otherwise, it shall be classified in Class 8. 5.5.1.4 Liquids with toxic vapors shall be classified in the following packing categories, where * is the density of saturated vapor at 21°C and standard atmospheric pressure, expressed as the number of mol/l per cubic meter of air: Class X packing (e.g. c10LC and 110mL/m2); Class 0 packing (e.g. 0LC and LC3 ((0l,/m2;
t)m); US packing (e.g. c1/5LC% and tG% 5000mL/m2); 5.5.2 Classification of mixed packing categories (e.g. tt||); 5.5.2.1 Packing categories of liquid mixtures with inhalation toxicity; 5.5.2.1.1 When the composition is When the 1.C value of each non-toxic substance in a mixture is known, the packing category shall be determined in accordance with Article 3.6.2.2.4.7 of the Joint Recommendation on the Transport of Dangerous Goods (19th revised edition). 5.5.2.1.2 When the 1.C value of a mixture is determined by technical judgment, the classification is shown in Table 2. Table 2 Classification of packing categories for mixtures with unknown 1.C value Packing category High hazard level Some range of hazard level Low hazard level Safety precautions C 000
Report limit test.R101.C.
: limit test 23
Required limit test 4R.C
Inhalation limit test: 09mL/,
Desorption test control h,Ra1/aiCsr
5.5.2.2 Special delineation of packaging for compound products with oral and percutaneous acute fungicide properties The method for delineating the packaging category for compound products with oral and percutaneous acute fungicide properties shall refer to the joint standard for the transport of hazardous substances 43 (13th revised edition)> Article 2.6.2.3 6 Inspection rules
6.1 Slow inspection items
Inspect item by item according to the requirements of Chapter 4 and Article 5 of this standard. 6.2 Light inspection items
When any of the following situations occurs, conduct a risk compliance inspection:) When a new product is put into production and then converted to an old product; h) After formal production, if there are major changes in materials and processes that may affect product performance: During normal production, once a year; d) After product calibration, when production is resumed: When there is a significant difference between the factory inspection results and the previous hazardous characteristics inspection results; the national quality supervision agency proposes to conduct hazardous characteristics verification. 6.3 Judgment rules
GB 19521.7—2004
Conduct tests according to Articles 5.1 to 5.4 of the technical standard, and determine the hazardous characteristics and packaging categories of toxic dangerous goods based on the test results and the requirements of Article 5.5 of this standard.
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