GB/T 27841-2011 Industrial chemicals Determination of water solubility of highly soluble solids and liquids Flask method GB/T27841-2011 Standard compression package decompression password: www.bzxz.net
This standard specifies the method for determining the water solubility of industrial chemicals (hereinafter referred to as products) by the flask method. This standard is applicable to basically pure substances with good stability and high solubility in water (greater than 10-2g/L). This standard is not applicable to impure products (such as certain surfactants), unstable products and products that are unstable in water. The presence of impurities in the test material will greatly affect the water solubility determination results of the substance; it is not applicable to basically pure substances with good stability in water but low solubility (less than 10-2g/L).
This standard was drafted in accordance with the rules given in GB/T1.1-2009. This standard has the same technical content as NFT20-046:1985 "Determination of water solubility of solids and liquids with high solubility for industrial chemicals by flask method" (French version).
For ease of use, this standard has been modified as follows:
———The footnote (1) in the original French standard 6.3 has been removed and replaced with a paragraph note;
———A chapter "Normative references" has been added, in which GB/T22227 "Determination of water solubility of solids and liquids with low solubility for industrial chemicals by column chromatography" has the same technical content as the French standard NFT20-045:1985;
———Among the normative references, ISO4788 "Laboratory glassware graduated cylinder" has the same degree of consistency as the French standard NFB35-302.
This standard is proposed and managed by the National Technical Committee for Hazardous Chemicals Management Standardization (SAC/TC251).
The drafting units of this standard are: China Institute of Inspection and Quarantine, China Chemical Economic and Technological Development Center, Jiangsu Coal Chemical Engineering Design and Research Institute Co., Ltd., and Sinochem Chemical Standardization Research Institute.
The drafters of this standard are: Zhang Jing, Chen Huiming, Wang Xiaobing, Yang Ting, and Guo Xinyu.
The following documents are indispensable for the application of this document. For any dated referenced document, only the dated version applies to this document. For any undated referenced document, its latest version (including all amendments) applies to this document.
GB/T22227 Industrial chemicals Determination of water solubility of solids and liquids with low solubility Column chromatography method
ISO4788 Laboratory glassware—Graduated measuring cylinders

ICS 13. 300;11. 100
National Standard of the People's Republic of China
GB/T 27841-—2011
Chernical products for industrial use--Determination of hydrosolubility olsolids and liquids with high solubilityFlask method2011-12-30 Issued
General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China Administration of Standardization of the People's Republic of China
2012-08-01 Implementation
GB/T 27B41—2011
This standard was drafted according to the rules given in GB/T 1.1—2009. This standard has the same technical content as NFT20-016:1985 Industrial chemicals with commercial solubility - Determination of water solubility of solids and liquids - Flask method (French version). For ease of use, this standard has been edited as follows: the footnote (1) in the original French standard 6.3 has been removed and replaced with a paragraph note; a chapter on "normative references" has been added, in which GB/T22227 "Industrial chemicals with low solubility - Determination of water solubility of solids and liquids - Column chromatography method" is consistent with the technical content of French standard NF20-045:1985; ISO4788 laboratory glassware blood volume fraction in a normative reference document is equivalent to the French standard NFB35-302.
This standard was proposed by the National Technical Committee for Standardization of Hazardous Chemicals Management (SAC/TC251) and is under the jurisdiction of H. The drafting units of this standard are: China Institute of Inspection and Quarantine, China Chemical Economic and Technological Development Center, Jiangsu Coal Chemical Engineering Design and Research Institute Co., Ltd., Sinochem Chemical Standardization Research Institute, and the drafters of this standard are: Zhang Jing, Chen Huiming, Xiao Bing, Yang Ting, Guo Xinyu. TTTKANYKACA
GB/T 27841—2011
The test method in this standard cannot determine the water solubility of all substances. The following two determination methods can be used respectively: for testing basic pure substances with high solubility (greater than 10-2&/1.) and stable in water, refer to the determination method of this standard; for testing basic pure substances with low solubility (less than 10-\ more/L) and stable in water, refer to the national standard GB/T22227. GB/T22227&T. Determination of water solubility of solids and liquids with low solubility for industrial chemicals
Chromatography" is a national standard issued in 2008, which has the same technical content as the French standard NFT20-045:198. As of the publication of this standard, the International Organization for Standardization (ISO) has not developed any relevant international standards. The content of this standard is consistent with the method described in A.6 of Commission Directive 84/449/EEC, which is based on the Organization for Economic Cooperation and Development (OECD) Guidelines for Chemical Testing Methods No. 105.
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1 Scope
Industrial chemicals: Determination of water solubility of solids and liquids with high solubility Flask method
This standard specifies the method for determining the water solubility of industrial chemicals (hereinafter referred to as products) using the flask method.CB/T 27841—2011
This standard is applicable to basically pure substances with good stability and high solubility in water (greater than 10-g/L). This standard is not applicable to impure products (such as certain surfactants). Unstable products and products that are unstable in water. The presence of impurities in the test material will greatly affect the water solubility test results of the substance; it is not applicable to basically pure substances with good stability but low solubility in water (less than 102/L).
2 Normative references
The following documents are essential for the application of this document. All references with dates , only the dated version applies to this document. The latest version of any undated referenced document (including all amendments) applies to this document. GB/T 22227 Industrial chemicals - Determination of water solubility of solids and liquids with low hydrolysis - Column chromatography ISO 4788 Laboratory glassware - Graduated measuring cylinders 3 Terms and definitions
The following terms and definitions apply to this document.
The hydrosolobility of the product of products The mass concentration of the product in the saturated state in water at a specified temperature, expressed in kg/㎡ or g/L. 4 Principle
Under conditions slightly higher than the measurement temperature, the product is dissolved in water until it reaches a saturated state. The solution is cooled and maintained at the measurement temperature, and the mass concentration of the saturated state is kept constant by stirring. A certain volume of saturated solution is extracted and the mass concentration of the product in the saturated state in water is determined by an appropriate analytical method. 5 Reagents
Distilled water or equivalent purified water.
6 Test instruments and equipment
6. 1 Ground flask with scale: 10 mL and 100 mL ground flasks that meet the requirements of standard IS0 4788, 6.2 Mechanical stirrer.
6.3 Temperature control box: accuracy of ±0.5℃
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GB/T 27841—2011
6.4 High-pressure equipment.
7 Test procedure
7.1 Test temperature
Test temperature is 20℃±0.5℃. If the effect of temperature change per degree Celsius on solubility is greater than 3%, two other temperatures at least 10℃ higher or lower than the original operating temperature should be selected. 7.2 Preliminary test
In a 10mL flask (see 6.1), add about 0.1% sample (solid sample should be ground into powder) and gradually add distilled water at room temperature
After each addition of a certain amount of water, shake the mixture in the flask vigorously for 10 minutes to observe whether there is any undissolved sample. After adding 10mL, if the sample is not completely dissolved, transfer the contents of the flask to a 10mL flask (see 6.1), add more water and repeat the above test. The dissolution process of some low-solubility substances requires a considerable amount of time (at least 24 hours). Table 1 provides the approximate solubility based on the volume of water added to completely dissolve the sample. If the product still does not dissolve, it should be re-diluted to confirm whether column chromatography is required, see GB/T 22227. Table 10.1 Estimated solubility of g sample
Amount of water added/bzxz.net
Approximate solubility
7.3 Determination
1000~200
200-100
100--50
7.3.1 Based on the results of the preliminary test (see 7.2), estimate the total amount of sample required to achieve saturation in the selected volume of water. The volume of water should depend on the intended analytical method and the solubility range. 7.3.2 Weigh 3 portions of sample approximately equal to 5 times the total amount of sample estimated above and place them in 3 grinding flasks with a volume appropriate to the selected volume of water. Add the same volume of water as before to each flask. 7.3.3 Cover the flasks and place them in a thermostat at 0 °C. Stir the mixture with a vigorous stirrer for 24 h. After that, keep them at the highest temperature for 24 h, stirring the mixture occasionally. Then centrifuge the contents of the flasks at the test temperature and extract the transparent solution. Then determine the mass gain of the product at saturation by analytical method. Note: Select the specific analytical method for the product and consider the solubility impurities that may cause significant errors in the determination of the solubility. Place the other two flasks in a thermostat at 30 °C for 48 h or 72 h respectively, and then operate the two flasks in the same way as above. If the mass concentration of the product at saturation in the two flasks meets the reproducibility requirements of the method, the test is considered successful. On the contrary, if the mass gain increases with time, the entire test should be repeated with a longer dissolution time, for example, the mass gain of the product in the two flasks is determined every 24 h until it meets the reproducibility requirements of the method. 7.3.4 Indicate the pH value of each sample.
8 Expression of results
8.1 Expression method
Express the solubility of the product at a specified temperature in units of /m2, that is, the average value of the mass concentration of the product under saturated state obtained by measuring three flasks separately.
8.2 Repeatability test
GB/T 27841—2011
The maximum difference between the results of two simultaneous or consecutive measurements of the same sample by the same analyst using the same instrument and equipment shall not exceed 15% of the average value. 9 Test report
The test report shall at least contain the following parts:a)
Detailed description of the test substance (physical properties and purity)1b)
Numbering method:
Analysis method
Analysis results of individual samples and average analysis results, as well as the following supplementary information:1) pH value of each sample:
2) Test temperature;
Test result expressed as the average value of three consistent measurements;e)
All special details recorded during the measurement process; all records of operations not specified in this standard or any other operations. TTTKANTKACA
GB/T 27B41—2011
Reference literature
[1_Law No 82-905 of 21 October 1982 atnending Law No 77-771(0J of 21 Octobcr 1982)[2]
Council Directive 67/548/EEC af 27 Junc 1967(0J No I. 196 of 16 August 1967.P. 1)Directive 79/831/EEC of 18 September 1967(OI No L259 of 15 October 1979,p.10)Directive 84/419/EEC of 25April1984(OJNo, L251 of 19 August 1984,p.1)OECD guideline for the testing of chemicals,No.105Water Solubility,OECD-PARIS,1981
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